Postoperative pyoderma gangrenosum in a patient with HLA-A26/B51 following hysterectomy and bilateral oophorectomy: a case report
- By Nobushige Kohri,
- Ken Shiraishi,
- Satoshi Yoshida,
- Katsuhiko Nishihara,
- Kazuki Yatsuzuka,
- Jun Muto
- and Yasuhiro Fujisawa
Pages 53 to 55
Cite this article
- KOHRI, Nobushige,
- SHIRAISHI, Ken,
- YOSHIDA, Satoshi,
- NISHIHARA, Katsuhiko,
- YATSUZUKA, Kazuki,
- MUTO, Jun
- and FUJISAWA, Yasuhiro,
- Kohri, Nobushige.,
- et al.
- Kohri, N.,
- Shiraishi, K.,
- Yoshida, S.,
- Nishihara, K.,
- Yatsuzuka, K.,
- Muto, J.
- and Fujisawa, Y.
https://doi.org/10.1684/ejd.2026.5020
Cite this article
- Kohri, N.,
- Shiraishi, K.,
- Yoshida, S.,
- Nishihara, K.,
- Yatsuzuka, K.,
- Muto, J.
- and Fujisawa, Y.
- Kohri, Nobushige.,
- et al.
- KOHRI, Nobushige,
- SHIRAISHI, Ken,
- YOSHIDA, Satoshi,
- NISHIHARA, Katsuhiko,
- YATSUZUKA, Kazuki,
- MUTO, Jun
- and FUJISAWA, Yasuhiro,
https://doi.org/10.1684/ejd.2026.5020
Pyoderma gangrenosum (PG) is a rare inflammatory neutrophilic dermatitis characterized by painful and rapidly progressing skin ulcers, and is often associated with underlying inflammatory bowel disease or malignancies [1]. It is classified alongside Behçet disease and Sweet syndrome as a neutrophilic dermatitis [2]. PG diagnosis is made by excluding other conditions. Clinical assessment by a dermatologist is essential [1]. PG may arise spontaneously or be triggered by trauma or surgical procedures (pathergy) [1]. We report a patient with PG that developed following total hysterectomy and bilateral oophorectomy. The patient had a family history of PG and was positive for HLA-A26/B51, an allele combination known to be associated with Behçet disease.
The patient was a woman in her 70s. One week after undergoing total hysterectomy and bilateral salpingo-oophorectomy for uterine cancer, she developed fever and a painful rash around the abdominal surgical wound, suggesting postoperative infection. Her medical history included aortic valve stenosis and exertional angina. There was no history of inflammatory bowel disease, rheumatoid arthritis or haematological diseases, including myelodysplastic syndrome. Her sister had previously been diagnosed with PG. On examination, infiltrative purpura with exudate was observed around the wound (figure 1A). Laboratory tests revealed elevated inflammatory markers: white blood cell count at 30,400/μL (normal range: 3,500-9,100/μL), CRP at 32.62 mg/dL (normal <0.2 mg/dL), and procalcitonin at 3.62 ng/mL (normal <0.5 ng/mL)…
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