Integrating experimental and computational methods to uncover the anti-inflammatory, anti-nociceptive and antioxidant properties of Alchemilla vulgaris
- By H. Saiah,
- W. Saiah,
- F. Nehal,
- M. Mokhtar
- and T. Aburjai
Pages 274 to 294
Cite this article
- SAIAH, H.,
- SAIAH, W.,
- NEHAL, F.,
- MOKHTAR, M.
- and ABURJAI, T.,
- Saiah, H..,
- et al.
- Saiah, H.,
- Saiah, W.,
- Nehal, F.,
- Mokhtar, M.
- and Aburjai, T.
https://doi.org/10.3166/phyto-2024-0421
Cite this article
- Saiah, H.,
- Saiah, W.,
- Nehal, F.,
- Mokhtar, M.
- and Aburjai, T.
- Saiah, H..,
- et al.
- SAIAH, H.,
- SAIAH, W.,
- NEHAL, F.,
- MOKHTAR, M.
- and ABURJAI, T.,
https://doi.org/10.3166/phyto-2024-0421
Medicinal herbs have been used to treat a variety of diseases since the dawn of time. They are known to be a good source of bioactive substances [1, 2]. According to several lines of research, secondary plant metabolites like flavonoids and phenolic acids may function as antioxidants and counteract the harmful effects of an imbalance between the production of enzymatic and non-enzymatic antioxidants and an excess of free radicals in oxidative stress [3].
One of these plants with medicinal properties that can provide practical means for the treatment of different ailments is Alchemilla vulgaris L. (Rosaceae), commonly known as lady’s mantle and bear’s foot [2]. A. vulgaris L. has been given several names by various ethnic groups; in Algeria, it is known as “Rejel Alasad” [4]. The herbaceous Alchemilla species are found in wet meadows in Europe, western Asia, and North America.Alchemilla species have been shown to exhibit biological effects that include antiviral, antioxidant, antiproliferative, and antibacterial activity [4]. Due to its potent astringent, antibacterial, and anti-inflammatory characteristics, A. vulgaris has been used as a treatment for bleeding, eczema, ulcers, and gastrointestinal problems, and to enhance wound healing. The Lady’s Mantle also functions as a diuretic and anti-anemic [4].
In Southeast Europe, the Lady’s Mantle is mostly used to avoid women’s health issues such as polycystic ovaries, oligomenorrhea, dysmenorrhea, endometriosis, fibroids, cysts, and infertility…
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