Evaluation of the antimicrobial and cytotoxic potential of a disinfectant solution based on Juglans regia extract against infections in orthopedic surgery
- By N. Djairene,
- H.S. Cherif,
- F. Hamaidi-Chergui
- and S. Azrou
Pages 296 to 302
Cite this article
- DJAIRENE, N.,
- CHERIF, H.S.,
- HAMAIDI-CHERGUI, F.
- and AZROU, S.,
- Djairene, N..,
- et al.
- Djairene, N.,
- Cherif, H.-S.,
- Hamaidi-Chergui, F.
- and Azrou, S.
https://doi.org/10.3166/phyto-2025-0480
Cite this article
- Djairene, N.,
- Cherif, H.-S.,
- Hamaidi-Chergui, F.
- and Azrou, S.
- Djairene, N..,
- et al.
- DJAIRENE, N.,
- CHERIF, H.S.,
- HAMAIDI-CHERGUI, F.
- and AZROU, S.,
https://doi.org/10.3166/phyto-2025-0480
This study aimed to determine the chemical composition and assess the antimicrobial activity and cytotoxicity of the ethanolic extract of Juglans regia L., with a view to its potential incorporation into a pharmaceutical formulation. Phytochemical screening by high-performance liquid chromatography (HPLC) revealed a significant presence of phenolic compounds in the ethanolic extract. The chromatographic profile indicates the presence of phenolic acids, flavonols, flavones, and flavanols. Antimicrobial testing performed on 92 bacterial strains responsible for post-operative infections in orthopedic surgery revealed antimicrobial activity against all tested strains. The ethanolic extract showed no toxicity to red blood cells, while viability levels of granulocytes and lymphocytes exceeded 70%. Given the effectiveness of this disinfectant solution, its use as a natural product for post-surgical disinfection appears very promising in the fight against orthopedic infections.